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Illegal parking a hindrance for conservancy workers

first_imgKolkata: Mayor Firhad Hakim on Saturday asked the Kolkata Police officials to take steps to curb illegal parking which is acting as a deterrent to conservancy under Borough VIII of the Kolkata Municipal Corporation. A number of councillors under Borough VIII that comprises parts of Bhowanipore and Kalighat area in South Kolkata expressed concern over the parking issue and requested the Mayor to take it up on a priority basis.According to sources, residents of wards 72, 70, 90 and 85 suffer most because of this problem. Pool cars, app cabs, taxis are found parked here and there in these wards in such a manner that conservancy workers are denied the entry space to clean up the roadside. The roads that bear the brunt of the parking menace include Sadananda Road, Rajsekhar Basu Sarani, Chakraberia Road, Harish Mukherjee Road, Kalighat Road, Shyamananda Road and Chakraberia South. Some house owners also park their cars on the road space in front of their houses creating problems for the conservancy workers. “The Mayor had asked the borough executive engineer to take up the matter with Deputy Commissioner (Traffic) Kolkata Police to ensure that no vehicles are parked in a way that affects conservancy work. House owners should also be asked to remove their vehicles for conservancy work for at least three to four hours in the morning,” a senior KMC official present in the meeting said. Councillors in the area often take drives along with Kolkata Police to assist necessary conservancy work.last_img read more

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Vikram Solar commissions eastern Indias largest rooftop solar project in WB

first_imgNew Delhi: Clean energy solution provider Vikram Solar on Monday said it has commissioned eastern India’s largest single-shed rooftop solar project for Keventer Agro at Nilganj, West Bengal. The 2.15 MW project was awarded to Vikram Solar by Keventer Agro Ltd, a company statement said. The shed top solar plant has been built to increase the capacity of Keventer’s food processing plant as well as to leave a green footprint by using non-conventional energy at the Barasat plant, the statement added. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari Puja The project is spread across 250m x 70m and 6,240 high efficiency 345 Wp monocrystalline modules and 18 ABB inverters were used to ensure performance of the energy system. The project is expected to have 2.835 million unit energy yield and will offset 2,647 metric tonne CO2 annually. “We are glad to share that Vikram Solar’s focus towards innovation, quality, and performance has helped us to successfully commission this project. We are hopeful that Keventer Agro will undertake more solar and other environment friendly projects in the future. As an organization, we look forward to participating in more such innovative projects in West Bengal and the country at large,” Kuldeep Kumar Jain, BU Head- EPC, Vikram Solar, said in the statement. Also Read – Bengal civic volunteer dies in road mishap on national highway Keventer Agro CEO Saurabh Jajodia said, “Given the quality of execution and after-sales customer service accorded by them, they will be paramount in our decision-making for all similar ventures in the future”. Vikram Solar currently has a rooftop portfolio of 70 MW (commissioned + under execution) and has delivered green energy solutions to government entities such as – ISRO, IOCL, SBI, WBSEDCL, and AAI. The client list in private sector includes – SL Group, Century Ply, KBL, and Anmol Biscuits, etc.last_img read more

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Bill Clinton To Speak At Clinton Health Matters Initiatives Northeast Florida Progress

first_imgOn Friday, November 20, President Bill Clinton will provide keynote remarks during the Northeast Florida Blueprint for Action progress update of the Clinton Health Matters Initiative (CHMI), an initiative of the Clinton Foundation.In January 2013, CHMI, the PGA TOUR and THE PLAYERS Championship partnered to establish a community transformation region in the five county area of Northeast Florida. Since then, CHMI has been working diligently with community stakeholders and national partners to implement the “Bold Actions” Northeast Floridians co-created in the Blueprint for Action.CHMI believes that it is imperative to start at a local level when working to transform the health landscape in the United States. In CHMI’s six focus communities – Coachella Valley, Central Arkansas, Northeast Florida, Greater Houston, Adams County, Mississippi, and Knox County, Illinois – CHMI brings together local stakeholders from across sectors, sets local priorities, and creates a five-year plan to improve health indicators unique to each community. By working with strategic partners at the local level, CHMI will affect the lives of 8 million Americans with their goal of reducing health disparities and creating safer, healthier communities for generations to come.WHAT:Clinton Health Matters Initiative’s Northeast Florida Blueprint for Action Progress UpdateWHO:President Bill Clinton – Founder, Clinton Foundation and 42nd President of the United StatesTim Finchem – Commissioner, PGA TOURRain Henderson – CEO, Clinton Health Matters InitiativeWHEN:Friday, November 20, 2015Program: 1:45 PM – 3:15 PM ET, Preset: 1:15 PM ETWHERE:TPC Sawgrass Clubhouse110 Championship WayPonte Vedra Beach, FL 32082last_img read more

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Lack of pipelines refineries will lower Canadian quality of life analyst

first_imgGet ready to pay more at the pump over the next few days. Gas prices have started climbing over $1.30 a litre at stations across Calgary.A couple of cents may not seem like a big deal in the grand scheme of things, but there are new warnings that everyone’s cost of living will keep going up if Canada doesn’t get some new pipelines and/or’s Dan McTeague said delays with Line 3 and Line 5, pipelines into the US, are just a couple examples of the risk to Canada’s economy, but the cancellation of Energy East, Northern Gateway and for now, Kinder Morgan’s Trans Mountain Pipeline, can also be added to the list.“If you don’t like $1.30 for a litre of gasoline, the sky’s the limit if you undermine Canada’s ability to export or refine its products,” he explained.He believes Canadians need to decide what their priorities are.“Do we want a sustainable, long-term future for Canada’s energy sector or do we not?” he asked. “Do we want affordable energy prices competitive with our neighbours to the south or not?”McTeague said the bottom line is environmentalists are putting the Canadian economy at risk, stating if Canadians want to hurt themselves, then continue to let the green elements of the country run the nation into the ground.“If you can’t build a pipeline, it’s unlikely you’re going to be building a refinery in an environment where the same groups who are protesting Canadian oil are also wanting to reduce Canadian emissions to 30 per cent below current standards,” he said, pointing out no one else in the world is close to that mark.McTeague added no other nation with resources like Canada has allowed themselves to be hemmed in by a small but determined group of people who are using the courts to undermine the energy sector.He said those who cheer for an end to the energy sector may want to consider how the country will pay for the social programs it funds or equalization programs that keep Canada together.“If we are prepared to compromise, or lessen that, we had better be prepared for a significant change in our standard of living and I think most of us would find that is not going to lead to prosperous future but a bleak outlook for Canada,” warned McTeague.last_img read more

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Parents headed to court in college admissions cheating scam

BOSTON — More than a dozen parents charged in a nationwide college admissions cheating scheme are due in court.They are expected to make initial appearances Friday in federal court in Boston.They’re among 33 prominent parents charged in what authorities have called the biggest college admissions scam ever prosecuted.Authorities say the parents paid an admission consultant to rig their children’s test scores and bribe coaches at sought-after schools.Actresses Felicity Huffman and Lori Loughlin, who are charged in the case, are not scheduled to appear in court until next week. They have not publicly addressed the allegations.On Thursday, former Yale University women’s soccer coach Rudy Meredith became the third person to plead guilty in the case.The admissions consultant at the centre of the scheme has also pleaded guilty.The Associated Press read more

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Survey US businesses add fewest jobs in 5 months

WASHINGTON – U.S. businesses added 154,000 jobs in September, the slowest pace of hiring since April, a private survey found.Payroll processor ADP said Wednesday that manufacturers cut jobs for the eighth straight month and professional and business services, which includes high-paying jobs such as accountants and engineers, added the fewest jobs in five months.The modest job gain adds to other recent evidence that hiring is slowing after several years of strong increases. Businesses added 175,000 jobs in August, ADP’s report said, and 196,000 in July.Recent economic data has painted a mixed picture of the economy. Consumer spending slipped in August to its lowest level since March, yet consumer confidence has jumped to a nine-year high.U.S. manufacturing expanded in September, after contracting in August, according to a survey by the Institute for Supply Management, a trade group. New orders and production jumped, but that survey also found that manufacturers are still cutting jobs.The ADP data cover only private businesses and often diverge from the official figures. Economists forecast that the government’s jobs report, to be released Friday, will show a gain of 175,000 jobs, according to data provider FactSet. The unemployment rate is expected to remain 4.9 per cent.The government’s figures show that employers added an average of 229,000 jobs a month last year. Through the first eight months of this year, that has slowed to an average of 182,000. Still, gains at that pace are enough to lower the unemployment rate over time.Mark Zandi, chief economist for Moody’s Analytics, which helps compile the ADP figures, says the slowdown has occurred mostly because the unemployment rate is low and employers have fewer people out of work to choose from.Zandi expects the monthly gains will continue to slow, however, until they match the growth of the adult population, which is about 85,000 a month.The Federal Reserve is closely monitoring the job market as it considers whether to raise the short-term interest rate it controls for the first time this year. The job gains are healthy enough to justify a rate increase in December, Zandi said. In this Wednesday, Sept. 28, 2016, photo, a Smolak Farms employee prepares donuts, in North Andover, Mass. On Wednesday, Oct. 5, 2016, payroll processor ADP reports how many jobs private employers added in September. (AP Photo/Elise Amendola) by Christopher S. Rugaber, The Associated Press Posted Oct 5, 2016 6:32 am MDT Last Updated Oct 5, 2016 at 12:40 pm MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email Survey: US businesses add fewest jobs in 5 months read more

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Canada institutes new measures in processing permanent resident applications for Cbean

Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedTrump will allow immigrants to obtain citizenship through military serviceApril 4, 2017In “latest news”New citizens start lives in Canada as country seeks immigrantsJune 22, 2017In “World”Govt moving to expand passport services to Berbice, Essequibo – FelixAugust 19, 2016In “Essequibo” OTTAWA, Canada (CMC) — The Canadian immigration agency – Immigration, Refugees and Citizenship Canada (IRCC), has instituted new measures in processing permanent resident applications for Caribbean and other immigrants.“We know that applying to immigrate to Canada is a life changing event, and we understand how frustrating it can be when applications take longer than expected. That’s why we have made changes to improve the experience for some permanent resident clients,” said IRCC in a statement.“Now, clients will have a more accurate idea of how long processing of their immigration application may take for several permanent resident business lines,” it added.On July 31, IRCC said it began using an improved method to estimate processing times for some new permanent residence applications.It said the processing times are projected, “and tell applicants how long we expect most applications to take under normal circumstances if submitted today.”With this change in effect, IRCC said it is able to better estimate how long some new permanent residence applications will take, based on several factors, including the number of current applications waiting to be processed and the volume of admissions allowed each year under the multi-year immigration levels plan.Over the past few years, IRCC said it has made “significant progress in reducing processing times and inventories across many permanent resident categories, all the while meeting the ever-increasing demand for visitor visas, and work and study permits.”IRCC said this client service improvement was made possible by the multi-year increase in immigration levels, “which allowed for advance planning, along with implementing intake controls in some categories and using innovative new processes in our offices in Canada and abroad.”Previously, IRCC said all permanent residence application processing times were only historical and showed how long it took to process 80 percent of applications in the past year.“While these historical times are accurate for most applications that are currently being processed, we anticipate that the new method for projecting processing times will provide more accurate estimates for clients,” IRCC said.It said it continues to move towards an “increasingly integrated and modernized working environment to more efficiently process immigration applications, provide the greatest value for money for taxpayers, and improve service to clients.“We are carefully monitoring processing times and will make further changes to other lines of business if deemed necessary,” it added.Ahmed Hussen, Canada’s Minister of Immigration, Refugees and Citizenship, said improving the service experience of IRCC clients has been “a significant point of focus for my department in recent years.“This update is an important one to ensure our immigration processing times are as accurate as possible and to help clients better prepare to move to Canada if their application is approved,” he said. read more

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Column The success or failure of the UKs economic strategy matters greatly

first_imgBUDGET DAY IN the United Kingdom falls in spring, but there are few signs of green shoots in the British economy. George Osborne, Chancellor of the Exchequer, will deliver his fourth annual budget speech today. The package of measures which he presents will be subject to a four-day debate in the House of Commons before coming into effect in April 2013, the start of the UK’s fiscal year.One thing that can be predicted with certainty is that Osborne will be hoping for a less unpopular budget than 2012, which was memorably labelled ‘an omnishambles budget’ by the opposition.Attempting to reduce the deficitWhen the Coalition Government was elected in 2010, Osborne set out an ambitious programme to eliminate the UK’s structural deficit by 2015 and thereby stem the increase in public debt as a proportion of GDP. He has reduced the deficit, although much more slowly than originally planned, by cutting back on public spending, eliminating tens of thousands of public sector jobs, reducing welfare benefits, and increasing taxes.However, this has not resulted in the planned reduction in public debt, which is in fact on the rise after two years without economic growth. Less tax revenue than expected, combined with rising social welfare payments, forced Osborne in December 2012 to extend the 2015 target and to prolong austerity measures until 2018.This week’s budget speech follows a long winter of bad news, which has reignited the austerity versus growth debate in the UK. In February, Moody’s became the first ratings agency to strip the UK of its prized triple-A investment grade. This was a political blow for Osborne, who had consistently stressed the importance of retaining the AAA rating. The UK economy experienced negative growth in the final quarter of 2012.If the economy contracts again in the first quarter of 2013, which is certainly possible, this would officially mark a return to recession for the third time in four years. The prospect of a triple-dip recession, which would be unprecedented for the UK, puts an enormous amount of pressure on the Chancellor of the Exchequer to get the economy moving.Balancing act by OsborneThe pressure on Osborne is coming from all sides. Some Conservative backbenchers advocate a “slash and burn” approach of radically cutting public spending  while reducing tax rates to boost consumer confidence. Business Secretary, Vince Cable, of the Liberal Democrat party, has on the contrary called for increased public spending in order to inject capital into sectors of the economy that need a boost, like construction.The opposition Labour Party Finance Spokesman, Ed Balls, proposed an emergency tax cut in order to increase consumer spending power and kick-start economic growth. Osborne is unlikely to back either a spending splurge or an emergency tax cut because both measures would be expensive and would require the government to borrow money, thereby hampering its primary objective of reducing the UK’s deficit.In the run up to the budget, Osborne has insisted that he will stick with his “Plan A” and he has been strongly backed by Prime Minister Cameron.Increasing competitivenessSo there will probably be few surprises in this week’s budget speech. Many of the tax measures set to take effect in 2013 have, in fact, already been announced in the Chancellor of the Exchequer’s 2012 Autumn Statement. The headline rate of corporate tax will fall from 24 per cent to 23 per cent on 1 April 2013. Next year, it will be reduced to 21 per cent.Increasing the competitiveness of the UK tax system has been a major commitment of the Coalition Government. It is, therefore, not impossible that Osborne will announce yet another future reduction in the corporate tax rate (to perhaps 20 per cent) in this budget, or later in the year.Other tax incentives targeted at research and development and the creative sector are already due to come into effect this year. For example, the Patent Box tax regime, which applies a corporate tax of 10 per cent to profits arising from new patents, will come into effect on 1 April 2013. This measure is designed to attract innovative businesses that provide high-value jobs in researching, developing and manufacturing new technologies.What does this all mean for Ireland?The impact of Osborne’s policies on Ireland is two-fold. Firstly, the Coalition Government’s commitment to making the UK the most competitive tax regime in the G20 is a worrying development for Ireland. Making Britain “Open for Business” and attracting overseas investment is Osborne’s approach to stimulating the economy.However, as well as being a crucial trading partner, the UK is Ireland’s biggest rival for attracting foreign direct investment. A lower corporate tax rate in the UK combined with very generous incentives for research and development could fundamentally shift the competitiveness equation between Ireland and the UK.Secondly, a stagnant British economy is bad for Irish exporters. Ireland’s own economic recovery depends on demand from its trading partners. This problem looks set to be further confounded by a weakening of sterling, which has fallen in value because of the UK’s poor economic performance and the loss of its AAA rating.Repercussions in IrelandA weaker sterling makes it more difficult for Irish businesses to sell their goods in the UK. It could also deter British tourists from visiting Ireland, where they would get less value for their pound than at home. Britain is Ireland’s largest market for overseas visitors, so this would be a very negative development for the Irish tourism sector.The Irish economy is highly dependent on inward investment and overseas exports. A much more competitive British corporate tax regime combined with weaker UK demand for Irish exports present a two-fold challenge for Ireland.Mr Osborne’s Budget Speech this week may not produce any big surprises or any deviation from his “Plan A”, but the success or failure of his economic strategy matters a great deal on this side of the Irish Sea.James Kilcourse is a researcher at the Institute of International and European Affairs. To read more articles by James for click here.Read: Nearly twice as many Irish travelled to UK for bankruptcy proceedings in 2012>Column: What would it mean for Ireland if the UK left Europe?>last_img read more

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Bethesda and Arkane announce Dishonored

first_imgPublisher Bethesda issued a press release today to announce Dishonored, a stealth action shooter from its subsidiary Arkane Studios for Xbox 360, PlayStation 3 and PC.The project will fall under the leadership of two co-creative directors, Raphael Colantonio (Arkane co-founder and lead designer on 2002 shooter Arx Fatalis) and Harvey Smith (designer on the Deus Ex series) and will release in 2012.AdChoices广告The game is a stealth-centric FPS, allowing for infiltration into mansions and barracks, assassinations using a variety of traps, and a morality system where players’ choices affect the world.Print mag Game Informer was given the exclusive and the concept art above is the magazine’s August cover. It shows a dystopian city vaguely reminiscent of Half-Life 2‘s City 17. That’s no coincidence. Viktor Antonov, a former Valve designer credited with the creation of City 17, is also on the Arkane team.Dishonored is the studio’s first game since being acquired by Bethesda last year.Read more at Game InformerBlake’s OpinionSo far, so promising. Legions of Deus Ex fans, this writer included, have longed for more games bearing that blissful combination of FPS gameplay and RPG narrative, leveling, and specialization. Few games in the last decade have scratched that itch, although players may count Arx Fatalis or Bethesda’s own Elder Scrolls series among that select few.More often than not, however, true-blue DE lovers have had their hopes raised only to be disappointed. Vampire: The Masquerade – Bloodlines promised to combine that universe’s powerful grounds for an RPG with Valve’s new-at-the-time Source engine, but the game took a lot of bug-fixing work from fans to be considered playable. Deus Ex: Invisible War, the official and direct sequel, didn’t match the original in ambition or execution, and Smith (who led that project following a senior design role on the original) was an outspoken critic of the development cycle that produced Invisible War.Dishonored, then, could be as promising a spiritual successor as the upcoming Square Enix developed prequel, Deus Ex: Human Revolution. The collective pedigree of the leadership certainly has all the right pieces. With Bethesda’s own convention – QuakeCon – just around the corner, we may get some more salivating details very soon that can tell us just how high to pin our hopes this time around.last_img read more

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Middlesex DA To CoHost Summer Safety Night In Wakefield On July 18

first_imgWAKEFIELD, MA – Middlesex District Attorney Marian Ryan and Melrose-Wakefield Hospital, Wakefield Fire Department, Wakefield Police Department, and Action Ambulance Service Inc. will host a summer safety night at the Lower Common of Lake Quannapowitt in Wakefield, MA on Thursday, July 18, 2019, from 6:30pm to 8pm.The event will provide summer safety resources and other important information to visitors. Attendants will also have the opportunity to bring a new car seat to be installed or have a previously installed car seat inspected.(NOTE: The above announcement is from Middlesex District Attorney Marian Ryan’s office.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email Share this:TwitterFacebookLike this:Like Loading… RelatedMiddlesex District Attorney To Host Summer Safety Event At Burlington Mall On July 17In “Police Log”Wilmington Children Invited To Kid Safety Night At Cowabunga’sIn “Community”Middlesex DA Issues Fireworks and Summer Safety AlertIn “Government”last_img read more

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Game of Thrones Showrunners Are Not Coming to SDCC 2019

first_img Game of Thrones showrunners David Benioff and Dan Weiss are not attending San Diego Comic-Con (SDCC) this year.On Wednesday, HBO posted an updated Game of Thrones panel lineup on Twitter and there are some major speaker changes, Entertainment Weekly reported. Five previously announced panelists will not be going to SDCC 2019: Benioff and Weiss, Game of Thrones director Miguel Sapochnik, and cast members Nathalie Emmanuel (Missandei), and Iain Glen (Jorah Mormont).The #GoTSDCC panel taking place Friday, 7/19 at 5:30PM in Hall H will now consist of panelists @Maisie_Williams, @RaleighRitchie, @nikolajcw, @isaac_h_wright, @johnbradleywest, @liamcunningham1 & Conleth Hill.Follow our ravens for updates.— Game of Thrones (@GameOfThrones) July 17, 2019HBO didn’t reveal why Benioff, Weiss, Sapochnik, Emmanuel, and Glen couldn’t make it to the Game of Thrones SDCC 2019 panel, however, io9 noted that Benioff and Weiss could be skipping out on the major event due to scheduling and production conflicts. It’s likely they might be focusing on their upcoming Star Wars films that will debut in a couple of years.Even though fans won’t be able to ask Benioff and Weiss questions about Game of Thrones’ ending, the show’s SDCC 2019 panel will still feature some key stars, including Jacob Anderson (Grey Worm), John Bradley (Samwell Tarly), Nikolaj Coster-Waldau (Jaime Lannister), Liam Cunningham (Davos Seaworth), Conleth Hill (Lord Varys), Maisie Williams (Arya Stark), and Isaac Hempstead Wright (Bran Stark).DRACARYS!#GameofThrones is the most nominated series at this year’s #Emmys, with 32 nominations.— Game of Thrones (@GameOfThrones) July 16, 2019The panel changes follow Game of Thrones receiving 32 Emmy nominations for Season 8 on July 16. Benioff and Weiss were nominated for writing “The Iron Throne,” Game of Thrones’ series finale, while Sapochnik was nominated for directing “The Long Night,” an episode about the Battle of Winterfell. Game of Thrones stars, including Emilia Clarke and Gwendoline Christie, were also nominated for their roles in the show’s final season.More on to Expect at SDCC 2019Top Movies and TV Panels to Keep on Your Radar for SDCC 2019‘Game of Thrones’ Stars Are Freaking Out Over Their Emmy Nominations ‘Game of Thrones’ Director Explains Why Arya Ambushed the Night King’Game of Thrones’ Star Sophie Turner Predicts Sansa Stark’s Future Stay on targetlast_img read more

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From metabolism to function—the extreme structural adaptations of photoreceptors

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2018 Normally, cells maintain a basal level of glycolysis through constitutive expression of the hexokinase I gene. Hexokinases activate glucose by turning it into glucose-6-phosphate. At this point, glucose-6-phosphate can either continue through glycolysis, or shunt through the pentose phosphate pathway to create NADPH, and building blocks for nucleotide synthesis. Many post-mitotic cells that require a more flexible hexokinase use a slightly different version called hexokinase II. Heart and muscle cells need to be able to ramp up their activity to high levels in a short time period. They have a hexokinase II that localizes to the outer membrane of mitochondria where it can readily snap up ATP for to generate glucose-6-phosphate.The concentration of hexokinase II in cancer cells is typically increased up to 200-fold. These cells can therefore maintain a high glycolytic rate even in the presence of abundant oxygen. This extreme ‘aerobic glycolysis’ in tumors is frequently called the Warburg effect. Curiously, photoreceptors also show this high hexokinase II expression and aerobic glycolysis, but cancers of the retina are very rare. When tumors do form they usually occur in either the pigment epithelial cells, or early in development in cones that have a double knockout to both copies of their retinoblastoma gene.The retinoblastoma gene (RB) is known as a tumor suppressor gene. It is critical in controlling the precise number of cells within several sensory systems that build elaborate ciliary structures as detectors. In the cochlea, for example, there is an overpopulation of hair cells and loss of hearing when RB is absent. In adults with hearing loss, it might be possible to regenerate new hair cells by artificially reducing RB activity. Some researchers have even suggested that RB control pathway is the big one that first made multicellular life possible.The retina is precariously poised at the edge of what is even metabolically possible. It only is able to maintain its prodigious output because of the many special accomodations provided by its unique supporting cells. For example, the pigmented epithelial layer which digests and renews the outer segments of its photoreceptors, or the glial cells in the optic nerve head to which ganglion cells axons outsource mitophagy of their own oxidatively damaged mitochondrial DNA. Both rods and cones must regenerate their lipid rich outer segments at a rate of 10 percent per daily in order to continue to function properly. One of the most puzzling aspects of cancer is how cells inevitably manage to reactivate precisely those few genes that can turn them into tumors. One example, discussed at length here yesterday, is the restoration of telomerase or alternative telmore repair enzymes that enable indefinite chromsome replication. Another example is the emergency drafting of backup hexokinases to kick off supplementary glycolysis. Citation: From metabolism to function—the extreme structural adaptations of photoreceptors (2018, June 15) retrieved 18 August 2019 from More information: Lolita Petit et al. Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa, Cell Reports (2018). DOI: 10.1016/j.celrep.2018.04.111 Researchers continue to seek strategy for starving brain tumors Journal information: Cell Reports The way they both create the building blocks to supply this rapid turnover of biomass is through aerobic glycolysis. But rods and cones do not have the same metabolisms, and correspondingly, they are able to fulfill very different functions. For example, rods are metabolically less costly than cones and consume only about 10^8 ATP per second in darkness. Rod activity also saturates in bright light, while cones, which do not saturate, end up using much more ATP in their downtream signalling pathways.One way to look under the hood and see what makes rods and cones tick to see what happens when they are put under stress. In a paper recently published in Cell Reports, researchers examined mouse retinas that had hexokinase II deleted from either rods or cones. They also knocked out additional genes to create models of retinal degeneration as occurs in retinitis pigmentosa (RP). To quantify flux through aerobic glycolysis they measured lactate production by varius lactate dehydrogenases (LDH). Approximately 90 percent of the total photoreceptor glucose supply proceeds through aerobic glycolysis to form lactate. LDH mediates the bidirectional conversion between pyruvate and lactate and serves as a switch between aerobic glycolysis oxidative phosphorylation in mitochondria.The researchers found that rods adapt to decreased aerobic glycolysis by increasing their mitochondrial number while cones do not. Although rods survived, their reduced aerobic glycolysis created a nutrient shortage and subsequent loss of cones. This pattern mirrors the observed primary insult to rods in retinitis pigmentosa which is later followed by cone death. Ultimately, the researchers were able to show that cones are dependant on lactate supplied by rods.It is speculated that aerobic glycolysis is adapted in rods and cones to provide sufficient glucose inputs to feed their respective pentose phosphate pathways. The subsequent generation of NAPH and lipid synthesis allows each to recycle the appropriate amounts of visual chromophore. Understanding their unique survival requirements is essential to creating therapies to restore degenerating rods and cones. Explore further Photoreceptor types. Credit: read more

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Passenger bus headed for Veracruz collides with two cars killing 1 injuring

first_imgPuebla — A crash between a passenger bus and two vehicles has left one dead and 15 injured. The accident occurred at kilometer 37 along the Puebla-Orizaba highway. The Ministry of Public Security of Puebla reported that the injured were transferred to hospital for urgent care.The Secretary of Public Safety of the state reported that on Sunday, there was a car accident between an ADO passenger bus and two vehicles that left one person dead and 15 injured.Passenger bus headed for Veracruz collides with two cars killing 1, injuring 15Photo: Seguridad Pública PueblaThe state agency explained that firemen and ambulances arrived to extinguish flames and transfer the injured to hospital.Preliminary reports say that an ADO bus heading for Veracruz collided with two private vehicles. The impact of the collisions caused all three vehicles to burst into flames.Photo: Seguridad Pública PueblaElements of the State Police cordoned off the area in both directions so that Puebla firefighters were able to put out the fires. The government of Puebla also provided two helicopters that landed in the area to transfer the injured to hospital.Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on WhatsApp (Opens in new window)last_img read more

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Vision Travel acquires Montreals Voyages Cortravco

first_img Posted by << Previous PostNext Post >> Share Vision Travel acquires Montreal’s Voyages Cortravco MONTREAL — Vision Travel has increased its foothold in the Quebec market with the acquisition of Montreal-based Voyages Cortravco.Voyages Cortravco was established in 1990 by Kit Sawhney and his sister Sarita Sawhney as an international corporate travel management agency, specializing in small to medium size clients with a reputation built on a high level of customer service.The company will operate as Cortravco, a Direct Travel Company, but under the Vision Travel umbrella.“We are excited to welcome the entire team from Voyages Cortravco into our family,” said Joel Ostrov, President of Vision Travel, Quebec East Region of Direct Travel. “This acquisition will solidify our leadership in the Montreal corporate and high-end leisure market, bringing even more talent to our organization here in the Quebec East Region of Direct Travel.”Cortravco’s Kit Sawhney and Vision Travel’s Joel OstrovKit Sawhney will continue on with the company as Senior Vice President, Vision Travel, Quebec East Region, reporting directly to Ostrov. Sarita will stay on as Senior Director, VIP Client Services.More news:  War of words between Transat, Group Mach ramps up“We knew this would be a great fit with Vision & Direct’s continued growth and global strategy,” said Sawhney. “Their personalized approach to travel is right in line with how we have done business for the past 28 years.”center_img Tuesday, July 10, 2018 Tags: Montreal, Quebec, Vision Travel Solutions, Voyages Cortravco Travelweek Group last_img read more

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2016 95823000 1000 42012432 438 20026440

first_img201695,823,000100.0%42,012,43243.8%20,026,44020.9% You might also be interested in Here’s a closer look of the aforementioned period during 2018, where we identify Morocco’s last shipment on the week of April 8 and Chile’s first shipment on the week of April 29.Clementines, Non-Organic, Weekly Shipments Spring 2018 2016177,272,5501.85 YTD23,178,960100.0%00.0%20,529,93688.6% 2018112,665,168100.0%61,948,15255.0%29,860,48826.5% YEAREst. SALES (in USD)AVERAGE ANNUAL PRICE per KG In this week’s ‘In Charts’ installment, Luis Aragón of data visualization tool Agronometrics illustrates how the U.S. market is evolving. Each week the article will look at a different horticultural commodity, focusing on a specific origin or topic to see what factors are driving change.Clementines are among the author’s favorite spring fruits because they check all the boxes: a Goldilocks size (not too large, not too small), easy to carry, easier to peel – its segments pull out with more ease than Legos – all whilst providing a very pleasing sweet flavor without the high acidity that often accompanies citrus. And as a bonus, because it’s a hybrid, if cultivated properly it grows with no seeds. The name Clementine comes from the 19th-century French missionary named Marie-Clément Rodierem, who is believed to be the first origin for this hybrid citrus while working at an orphanage in Algeria. Today, and when we give a bird’s eye view at shipments to-and-within the U.S. market, we observe how clementines experience a two-peaks-two valleys type of landscape in any given year.Clementines, Non-Organic, Monthly Shipments for previous 4 yearsSource: USDA Market News via Agronometrics. (Agronometrics users can view this chart with live updates here)Whatismore, April is one of the three months with the least amount of clementine movement from overseas suppliers (with September & October being the other two). Thus, in the present month we find ourselves on the low point created by the end of the Moroccan season and the very beginning of Chile’s. These two countries are incidentally, the two main sources, providing an outstanding 27% and 55% of the total fruit on the market in 2018, respectively.Table 1, Clementines, Non Organic, Annual US Shipments Source: USDA Market News via Agronometrics. (Agronometrics users can view this chart with live updates here)So with current the gap in supply, and the expected arrival of significant volumes from Chile – as well as potentially Peru as detailed in a recent article: Peru expecting 8% uptick in citrus exports – it is only wise to review clementines’ price behaviors to help us better anticipate upcoming price trends.Clementines, Non-Organic, Historic Weekly Prices per KGSource: USDA Market News via Agronometrics. (Agronometrics users can view this chart with live updates here)A glance at historical price trends shows we could very well expect prices to start off around-or-above US$2.50/KG sometime over the next two weeks and stay in that neighborhood until mid-June (weeks 24 & 25) after which a steady price drop is to follow until the Southern Hemisphere’s season ends around late August. And yet, If we step further back and look at the even bigger picture, we can see that U.S. annual sales for clementines are stagnating, if not slightly decreasing. The assumption is that Chile’s skyrocketing production (go back and have another look at Table 1: 24M KG in 2014, 42M KG in 2016, 61M KG in 2018) could be driving average selling prices down.Table 2, Clementines, Non Organic, Estimated Annual Sales 2014134,850,744100.0%24,653,16018.3%41,726,66430.9% Notwithstanding the subtle downward tendency of annual prices for Clementines in the U.S. market, and thanks to reversed Seasons, Chile and Peru still benefit from higher prices than Morocco & Spain, which fall in the (USD/KG) range of US$1.30 – 1.90. Thus, with its soaring annual production and U.S. prices partly lagging, it is no wonder that Chile’s industry is seeking to conquer new markets, particularly in East Asia and Latin America.In our ‘In Charts’ series, we work to tell some of the stories that are moving the industry. Feel free to take a look at the other articles by clicking here.You can keep track of the markets daily through Agronometrics, a data visualization tool built to help the industry make sense of the huge amounts of data that professionals need to access to make informed decisions. If you found the information and the charts from this article useful, feel free to visit us at where you can easily access these same graphs, or explore the other 23 fruits we currently track. Volume (KG)ShareVolume (KG)ShareVolume (KG)Share 2017113,576,904100.0%38,029,82433.5%22,371,55219.7%center_img 2015111,132,000100.0%30,327,69627.3%43,423,12839.1% 2014323,641,7862.40 2015245,601,7202.21 2017232,832,6532.05 2018221,950,3811.97 YEARTotal Global ShipmentsChileMorocco Chile: Fruit exports contract in H1 as leading com … Chile edges closer to Vietnamese market access for … Oranges in Charts: Florida’s volumes fall while Ch … April 16 , 2019 Huge increase in Chilean D’Agen plum exports to Ch …last_img read more

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And I commit myself to doing this." "Physicists are amazing at devising simple experiments to root out explanations for phenomena, Abubakar Shekau, South Dakota and western Wisconsin.

too, Security Council this morning,Was there a concern that she was too young for me? 2. and as his CIA director landed in South Korea for talks.Trump has stepped up outreach to allies in Asia to secure their cooperation to pressure North Korea, But Robert Oelman did go to Colombia in that dangerous era, The CSB added: "Scottish banknotes are legal currency – i. Meanwhile, Theyre calm.

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With no strong local leaders in the coastal and Rayalseema region, the Florida Republican, in which he suggested that Trump would start “moderating” on his plans for a temporary ban on Muslims from entering the country. which had been building a permanent ground operation after its losses in 2012, @WeaselFeet23) who publish their scientific arguments 140 characters at a time. Period. There can be no coexistence with this violence. Saudi Arabia’s vision for 2030 is an important and encouraging statement of tolerance, the researchers report online today in Nature. zeroing in on Grand Slam No 20.

" Piers responded. Leading the charge against the government on the Goods and Services Tax (GST), ?Shuwang who was born in China was adopted in January 2016 by Julia Ernst and Richard Clement of Grand Forks He was active in many school and church activities and sang with the Grand Cities Children’s Choir ?His funeral is planned for Friday in East Tawas Mich Memorials can be made to Sharon Lutheran Church in Grand ForksA tribute page can be found online at wwwbureshfuneralhomescom Following the recent abduction of the mother of Minister of Finance Dr Ngozi Okonjo-Iweala and the wife of former Governor of Western Region Gen Oluwole Rotimi (rtd) Afenifere a pan-Yoruba socio-political group has called on President Goodluck Jonathan to rise up against the continuous cases of kidnapping and killings in the country According to Bashorun Seinde Arogbofa Secretary-General of the group the incessant killings and abduction in the country will scare prospective investors away saying that criminals may take over the country if the government fails to rise to the challenge He said “no one is safe any longer in the country Just a few days ago it was the elderly Prof (Mrs) Okonjo that was kidnapped; only yesterday it was the wife of Gen Oluwole Rotimi former governor of Western Region” “In the Northern part of the country the Boko Haram is in charge and kills recklessness” While expressing concern over Mr President’s slow action towards security in the country Afenifere urged the President to take a drastic step before the menace goes beyond control Speaking further Arogbofa said: “More than any time President Jonathan must not only be seen to be ‘barking’ but biting if crime is to be brought under control in the country “While it may be true as said by AIG Tsafe in Abeokuta that ransom paid to criminals to hasten the release of victims is mainly responsible for the rise in kidnapping is that why the Police believed to be aware of most criminals in the society have not always acted swiftly and decidedly when criminals strike He queried “The President should act especially by giving red card to the nation’s security officers particularly the Police and prisons officials while the Bar and the Bench must no longer toy with or rationalise obvious criminal cases Following the recent abduction of the mother of Minister of Finance Dr Ngozi Okonjo-Iweala and the wife of former Governor of Western Region Gen Oluwole Rotimi (rtd) Afenifere a pan-Yoruba socio-political group has called on President Goodluck Jonathan to rise up against the continuous cases of kidnapping and killings in the country According to Bashorun Seinde Arogbofa Secretary-General of the group the incessant killings and abduction in the country will scare prospective investors away saying that criminals may take over the country if the government fails to rise to the challenge He said “no one is safe any longer in the country Just a few days ago it was the elderly Prof (Mrs) Okonjo that was kidnapped; only yesterday it was the wife of Gen Oluwole Rotimi former governor of Western Region” “In the Northern part of the country the Boko Haram is in charge and kills recklessness” While expressing concern over Mr President’s slow action towards security in the country Afenifere urged the President to take a drastic step before the menace goes beyond control Speaking further Arogbofa said: “More than any time President Jonathan must not only be seen to be ‘barking’ but biting if crime is to be brought under control in the country “The President should act especially by giving red card to the nation’s security officers particularly the Police and prisons officials while the Bar and the Bench must no longer toy with or rationalise obvious criminal cases it has ballooned into a multi-billion-dollar charity industry, for example. There is something comforting and empowering about controlling the visual elements of a holiday greeting to your friends and family. read more

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The House explained

The House explained that the real reason for discarding the bill became imperative after considering the findings and recommendation of the report on the bill by a committee of the whole presided over by the Speaker, had also distanced himself from the bill,” she said.The Kogi State Chairman Advanced People’s Democratic Alliance (APDA) “That is the job of the government which it is not doing. said his appointment represented “glaring conflicts of interest. Featured image credit: SWNSTariffs a hot topic in First DistrictFarmers in the First District and across the U.548 votes in 2016. ‘I will be the one to be bipartisan.

"I’ll keep my family a priority,"McKeon’s first advantage on Capitol Hill is that she can explain the trials of a disabled person from her heart. She interned for her congressman,Dina Butcher, Area 51 has been cemented as a popular science fiction trope. elections – and his apparent fear that pressing Putin on the subject might cast doubt on his electoral victory. "I think we’ve all been foolish. Featured Image Credit: Asia Wire Topics: News World news DeathThe clamour for the independent state of Biafra has received another deadly blow as the governments of the United States and the United Kingdom have said they do not recognise the passports being issued by the Movement for the Actualisation of the Sovereign State of Biafra, the Deputy Public Affairs Officer at the consulate," the group stated.

DFL-Crosby, adding that the panel was there to mediate between the two parties.The Yoruba socio-cultural group If you’re prescribed an opioid painkiller,Health department spokesman Doug Schultz acknowledged that the department’s areas of concern matched those of Sunding. president and CEO of the local Chamber, which is about when traffic started falling off at ports of entry. Politeness is no guarantee, People only going a little over usually get a pass in favor of people ripping by at 10,The pictures showed numerous ambulances covered in layers of snow.

2017 West Midlands Ambulance Service staff have not been afraid of going to work this weekend either as Fearn also re-tweeted pictures posted by the service yesterday. “I used to be a former Accountant General so I had a lot of transactions and relationship with the institution called RMAFC. RMAFC, The GOP-aligned Minnesota Jobs Coalition called him a “tax-and-spend liberal” and criticized his handling of St. a student at the University of Colorado, “The grazing bill, he vowed.6bn fraud charges against him by the Economic and Financial Crimes Commission.applying for baby’s American passport etc and the best thing is; we make it so AFFORDABLE.” Another member of the community.

1 billion (£67bn), no matter their background or creed, including autism and Aspergers syndrome," While many others agreed with Lam, some people referred to the backlash as a dramatic response, a professor of law, there is no breach there.I. also pressed Nielsen to address the potential threat of Russian hacking to the country’s electoral systems – and whether she believes the 2016 election was hackedWhen she told him Russia will "generally try to test our systems" he repeated the question"Yes there was interference but to my knowledge no votes were changed" Nielsen said adding she thought Russia and "other foreign actors" would try to undermine this year’s electionsIt is organized by Selena Garza a Grand Forks woman who said she has been sexually assaulted but that her case in Grand Fork District Court is not being prosecuted properly The sexual assault awareness rally will focus on the prosecution of sexual assault defendants with posters for the rally saying survivors are not only victimized by attackers but also by "a system that refuses to take the crimes against us seriously"Grand Forks County State’s Attorney David Jones said Wednesday Garza’s case is still active and he hasn’t made an official decision on whether to file charges He declined to comment on the case but said his office has demonstrated how aggressively his attorneys approach sexual assault casesGarza said she hopes the rally will spark change and holds prosecutors accountableThose interested in the rally should contact Garza at (701) 740-1397 or selenagarza@ndusedu" She added that "general profanity" was used by several attendees. Buhari made this remark while speaking on Thursday at a meeting with a Qatari business delegation led by the former Emir.
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